Abstract:Functionalized ordered mesoporous sillica materials have uniform and adjustable pore diameters, regular pore channels, stable skeleton structures, easily modified inner surfaces, relative high specific surface area and high adsorption capacity, etc. They can be used for selective separation and enrichment of trace analytes in complicated samples of biology, medicine and environment. Thus, functionalized Ordered Mesoporous Sillica Materials are gained special attention for sample pretreatment application. This review gives an introduction to preparation of functionalized mesoporous silica materials and an overview of their applications on separation and enrichment of mental ions, sample pretreatments for organic pollutants and biomacromolecules.