陈章武,邹惠园,熊凯鹏,申贵隽.N-N二甲基甲酰胺/纳米银修饰电极的制备与应用研究[J].中国无机分析化学,2019,9(4):51-55.
N-N二甲基甲酰胺/纳米银修饰电极的制备与应用研究
Preparation and Electrochemical study of N-N Dimethylformamide / Nano-silver modified electrode
投稿时间:2019-03-08  修订日期:2019-04-11
DOI:10.3969/j.issn.2095-1035.2019.04.013
中文关键词:  N-N二甲基甲酰胺  纳米银  玻璃电极(ITO)  电化学响应  盐酸二甲双胍
英文关键词:n-n dimethylformamide  Nano silver  Glass electrode (ITO)  Electrochemical response  Metformin hydrochloride
基金项目:2018年大连大学大学生创新创业训练计划项目
           
作者单位
陈章武 大连大学 环境与化学工程学院
邹惠园 大连诚泽检测有限公司
熊凯鹏 大连大学 环境与化学工程学院
申贵隽 大连大学 环境与化学工程学院
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中文摘要:
      用N-N二甲基甲酰胺和纳米银对导电玻璃(ITO)进行修饰得到了N-N二甲基甲酰胺/纳米银修饰电极。研究了电极的电化学行为,在pH =6.64的PBS缓冲溶液中,盐酸二甲双胍在0.075~0.2 mg/mL浓度范围内与氧化峰电流呈现很好的线性关系,线性方程为y = 317.19x + 30.07 6,最低检出限为0.000 7 mg/mL,线性相关线性系数R2为0.959 5。平行测量5组数据,其RSD值为0.75%,在盐酸二甲双胍缓释片溶液中5次加标回收率平均值为100.96%。精密度和准确度的分析结果表明该方法可应用于药物中盐酸二甲双胍含量的测定。
英文摘要:
      N-N dimethylamide/nano-silver modified electrode was used to modify conductive glass (ITO) with N-N dimethylformamide and nano-silver. The electrochemical behavior of the electrode was studied. In PBS with pH 6.64 as buffer solution, metformin hydrochloride showed a good linear relationship with oxidation peak current within the concentration range of 0.075~0.2 mg/mL while linear equations was y = 317.19x + 30.07 6, and the minimum detection limit was 0.000 7 mg/ mL. The correlation linear coefficient r squared is 0.959 5. Parallel measurement of 5 sets of data with an RSD value of 0.75 per cent. In metformin hydrochloride sustained-release tablet solution, the average recovery rate was 100.96 per cent after 5 times of standard addition. The results of precision and accuracy analysis showed that this method can be applied to the determination of metformin hydrochloride in medicine.
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