Abstract:Differentiate N-(βaminoethyl)-?-aminopropyltrimethoxysilane(AEAPTMS) and 3-Mercaptopropyltrimethoxysilane (MPTMS) was added to tetraethoxysilane(TEOS) mixture respectively，get silica gel materials Separate bonded amino group and mercapto group.This material is used as the filling material of SPE column, the method for the determination of inorganic arsenic in marine products by inductively coupled plasma mass spectrometry (ICP-MS) with solid phase extraction was established.We study adsorption principle, adsorption performance and elution conditions of solid phase extraction column for inorganic arsenic，results show that this solid phase extraction column material has good selective adsorption capacity In the range of pH3-4,As (V) can be eluted with 2% nitric acid，As (Ⅲ) can be eluted with 2% nitric acid and 0.1mol/L KIO3 mixed solution.The standard addition recovery of the actual sample is between 73% and 103% ，the method has realized the rapid, convenient and accurate detection of inorganic arsenic in seafood samples.