Determination of Mercury in Mitotane by Inductively Couple Plasma-Mass Spectrometry(ICP-MS)
Received:March 14, 2013  Revised:April 25, 2013
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DOI:doi:10.3969/j.issn.2095-1035.2013.03.015
KeyWord:inductively couple plasma mass spectrometry(ICP-MS); mitotane; mercury; microwave digestion
                 
AuthorInstitution
CHEN Feiran 绍兴市质量技术监督检测院,浙江 绍兴
YAN Pingqiu 浙江苏泊尔制药有限公司,浙江 绍兴
ZHOU Muyan 绍兴市质量技术监督检测院,浙江 绍兴
HUANG Guoquan 浙江苏泊尔制药有限公司,浙江 绍兴
WU Jian 绍兴市质量技术监督检测院,浙江 绍兴
JIN Jing 绍兴市质量技术监督检测院,浙江 绍兴
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Abstract:
      This article introduced a sensitive, reliable and accurate approach for the determination of mercury in Mitotane using inductively couple plasma-mass spectrometry(ICP-MS). The focus of this work is to optimize sample pretreatment procedure by investigating digestion methods, choice of acid system, and the microwave digestion programs. Under the optimized conditions, the detection limit was 0.005 mg/kg. The relative standard deviation was 7.7% for six parallel sample analyses. The spike recovery was in the rang of 82.3%~85.7%. The method has high sensitivity, good stability and high accuracy.
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