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| Preparation and Electrochemical study of N-N Dimethylformamide / Nano-silver modified electrode |
| Received:March 08, 2019 Revised:April 11, 2019 |
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| DOI：10.3969/j.issn.2095-1035.2019.04.013 |
| KeyWord:n-n dimethylformamide; Nano silver; Glass electrode (ITO);Electrochemical response; Metformin hydrochloride |
| Author | Institution |
| chenzhangwu |
大连大学 环境与化学工程学院 |
| zhouhuiyuan |
大连诚泽检测有限公司 |
| xiongkaipeng |
大连大学 环境与化学工程学院 |
| shenguijun |
大连大学 环境与化学工程学院 |
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| Abstract: |
| N-N dimethylamide/nano-silver modified electrode was used to modify conductive glass (ITO) with N-N dimethylformamide and nano-silver. The electrochemical behavior of the electrode was studied. In PBS with pH 6.64 as buffer solution, metformin hydrochloride showed a good linear relationship with oxidation peak current within the concentration range of 0.075~0.2 mg/mL while linear equations was y = 317.19x + 30.07 6, and the minimum detection limit was 0.000 7 mg/ mL. The correlation linear coefficient r squared is 0.959 5. Parallel measurement of 5 sets of data with an RSD value of 0.75 per cent. In metformin hydrochloride sustained-release tablet solution, the average recovery rate was 100.96 per cent after 5 times of standard addition. The results of precision and accuracy analysis showed that this method can be applied to the determination of metformin hydrochloride in medicine. |
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