| In this paper, on the basis of the 2015 edition of Chinese pharmacopoeia, using atomic fluorescence spectrometry and inductively coupled plasma mass spectrometry for astragalus oral liquid in the lead, arsenic, cadmium, mercury, copper, zinc,nickel and chromium were determined, and the used reagents, vessel, cast time, within the target species and join method were optimized.Results show that before the sample processing for vessels with 30% nitric acid treatment, the acid time when more than 1.5 h, to join single internal standard manually,you can get more accurate and stable determination results, RSD are less than 4% for the determination of 8 kinds of element, Hg, As, Cu, Pb, Zn, Cd, Ni and Cr of detection limit were 0.089 u g/L, 0.21 u g/L, 0.45 u g/L, 0.15u g/L, 0.45 u g/L, 0.025 u g/L, 0.35 u g/L and 0.39 u g/L,The recoveries of 8 elements were between 92% and 114%.This method can detect trace elements with stable results, simple process and less possibility of introducing blank. |