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| Determination of Selenium in Infant Formula by Double Quadrupole Inductively Coupled Plasma Mass Spectrometry(ICP-MS/MS) with O2 Reaction Mode |
| Received:July 13, 2023 Revised:January 27, 2024 |
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| DOI：10.3969/j.issn.2095-1035.2024.04.015 |
| KeyWord:ICP-MS/MS; O2 reaction mode; Organic sensitization; infant formula; Selenium |
| Author | Institution |
| YUAN Kun |
浙江省食品药品检验研究院国家市场监管重点实验室功能食品质量与安全） 浙江省食品药品检验研究院浙江省市场监管保健食品质量安全重点实验室 |
| CHEN Jiawei |
浙江中医药大学医学技术与信息工程学院 |
| ZHAO Nana |
浙江省食品药品检验研究院国家市场监管重点实验室功能食品质量与安全） 浙江省食品药品检验研究院浙江省市场监管保健食品质量安全重点实验室 |
| MAO Sihao |
浙江省食品药品检验研究院国家市场监管重点实验室功能食品质量与安全） 浙江省食品药品检验研究院浙江省市场监管保健食品质量安全重点实验室 |
| Liang Jingjing |
浙江省食品药品检验研究院国家市场监管重点实验室功能食品质量与安全） 浙江省食品药品检验研究院浙江省市场监管保健食品质量安全重点实验室 |
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| Abstract: |
| When the selenium content in infant formula food was determined by inductively coupled plasma mass spectrometry, the content of selenium was often high due to its difficult ionization and mass spectrum interference. Sensitizing carbon-containing organic matter and interfering with different analysis modes were studied to establish a method for the accurate determination of selenium in infant formula by inductively coupled plasma-mass spectrometry. By analyzing the sensitization effect of different carbon containing organics, such as methanol, ethanol, isopropyl alcohol, n-butanol, investigating the influence of organic concentration in the range of 0% to 10%, and studying the anti mass spectrometry interference ability under different instrumental analysis modes such as standard mode (no gas mode), single pole helium collision mode (He mode), series helium collision mode (HeHe mode) and series oxygen reaction mode (O2 mode) , the best conditions for the analysis of selenium content in infant formula were determined. The reagent with the best sensitization effect was 5% n-butanol. Compared with other analysis modes, ICP-MS/MS with oxygen mode was more accurate in detecting selenium content in quality control samples of infant formula. The results indicated that, the calibration curves were linear in the range of 0.50-10.00μg/L and the correlation coefficients were more than 0.999, the average recoveries of Se in infant formula reached 95.33% -99.89%, the precision of method was less than 5%, and the method detection limits and quantification limits were 0.1 mg/kg and 0.4 mg/kg, respectively. Compared with the results pretreated by atomic fluorescence spectrophotometry for t-test, the detection values obtained by this method had no significance difference in various types of commercially available infant formula ( p＞0.05) . The method has the advantages of simple operation, low detection limit and accurate detection results, and is suitable for the accurate measurement of selenium in infant formula. |
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